Prior to re-joining Northern Trust in 2007, Gwyn was a macroeconomist with the International Affairs bureau of the U.S. Treasury Department in Washington, DC. She was the staff desk officer responsible for U.S.-China economic policy and capital markets development. She also held positions formulating U.S. policy toward the Asian Development Bank and managing a team of economists evaluating the lending and assistance programs of the multilateral development banks. Prior to Treasury, Gwyn worked for Enron as a manager in the Research Department evaluating risk of international capital investment and conducting economic forecasts and analysis.

During her first 13 years at Northern Trust, Gwyn managed the international product management team responsible for all aspects of the institutional custody product development process from concept to product roll-out. Gwyn spent three years in the London branch starting up the group of specialists responsible for on-line reporting of portfolio information for clients and fund managers in the UK, Europe, Africa and Asia.